Start Date

14-12-2016 10:35 AM

Description

This proposal suggests that a relationship exists between oxidative stress and neurodegeneration, specifically in diseases like Alzheimer’s. This may be proven by an assay run which quantifies malondialdehyde (MDA), a byproduct of the reactive oxygen species which can induce the oxidative stress. By quantifying this, a graph can be produced which may prove the relationship with a variety of brain lysates from patients who suffer from these diseases. If these results show a relationship, then a directed treatment may be developed to address the root of the problem instead of treating the neurodegenerative symptoms.

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Mentor: Deepa Dabir, Ph.D.

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Dec 14th, 10:35 AM

Mitochondrial Oxidative Stress Damage and its Role in Neurodegeneration

This proposal suggests that a relationship exists between oxidative stress and neurodegeneration, specifically in diseases like Alzheimer’s. This may be proven by an assay run which quantifies malondialdehyde (MDA), a byproduct of the reactive oxygen species which can induce the oxidative stress. By quantifying this, a graph can be produced which may prove the relationship with a variety of brain lysates from patients who suffer from these diseases. If these results show a relationship, then a directed treatment may be developed to address the root of the problem instead of treating the neurodegenerative symptoms.