Investigating Metal Cations as Potential Inhibitors of IAPP Aggregation: KCl, CaCl2, and CuCl2

Author

Megan Burke, Loyola Marymount UniversityFollow

Date of Completion

5-2-2016

Degree Type

Honors Thesis

Discipline

Chemistry (CHEM)

First Advisor

David Moffet

Abstract

IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.

Recommended Citation

Burke, Megan, "Investigating Metal Cations as Potential Inhibitors of IAPP Aggregation: KCl, CaCl2, and CuCl2" (2016). Honors Thesis. 106.
https://digitalcommons.lmu.edu/honors-thesis/106