Document Type
Article - pre-print
Publication Date
3-2016
Abstract
The extracts of 27 vegetables, spices and herbs were screened for their functional ability to inhibit the aggregation of islet amyloid polypeptide (IAPP, amylin) into toxic amyloid aggregates. The aggregation of IAPP has been directly linked to the death of pancreatic β-islet cells in type 2 diabetes. Inhibiting the aggregation of IAPP is believed to have the potential to slow, if not prevent entirely, the progression of this disease. As vegetables, spices and herbs are known to possess many different positive health effects, the extracts of 27 plants (abundant within the United States and spanning several plant families) were screened for their ability to inhibit the formation of toxic IAPP aggregates. Their anti-amyloid activities were assessed through (1) thioflavin T binding assays, (2) visualization of amyloid fibers using atomic force microscopy and (3) cell rescue studies. From this research, mint, peppermint, red bell pepper and thyme emerged as possessing the greatest anti-amyloid activity.
Original Publication Citation
Fuentes AL, Hennessy K, Pascual J, et al. Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid. Journal of herbal medicine. 2016;6(1):37-41. doi:10.1016/j.hermed.2015.11.001.
Publisher Statement
This is an author-manuscript of an article accepted for publication in Journal of Herbal Medicine. The published version of this record is available online at doi: 10.1016/j.hermed.2015.11.001.
Digital Commons @ LMU & LLS Citation
Fuentes, Ana Lucia; Hennessy, Kathleen; Pascual, Jacob; Pepe, Nicole; Wang, In; Chaggan, Cynthia; Martinez, Jessica; Rivera, Evelyn; Cota, Paola; Cunha, Christina; Nogaj, Luiza A.; and Moffet, David A., "Identification of Plant Extracts that Inhibit the Formation of Diabetes-Linked IAPP Amyloid" (2016). Chemistry and Biochemistry Faculty Works. 10.
https://digitalcommons.lmu.edu/chem-biochem_fac/10
