Start Date
17-12-2015 2:00 PM
Description
A main cause of Type-II Diabetes has been identified as the clumping and aggregation of certain proteins within the body. Misfolding causes these insoluble, fibrous proteins, known as amyloid proteins,, thus causing fibrous protein deposits within the body that lead to toxic effects. Islet amyloid polypeptide (IAPP) is the polypeptide known to result in protein misfolding and aggregation in the pancreas, but is present in both healthy and diabetes-affected individuals. IAPP, released by pancreatic B-cells, is secreted with insulin to maintain healthy glucose levels within the body, but cell conditions can cause IAPP to have amyloidogenic properties, thus killing such B-cells. Cations such as Na+, Zn+, Cu2+, have shown potential properties that can reduce or slow IAPP aggregation within the cell.
Amyloid Protein Aggregation in Type-II Diabetes
A main cause of Type-II Diabetes has been identified as the clumping and aggregation of certain proteins within the body. Misfolding causes these insoluble, fibrous proteins, known as amyloid proteins,, thus causing fibrous protein deposits within the body that lead to toxic effects. Islet amyloid polypeptide (IAPP) is the polypeptide known to result in protein misfolding and aggregation in the pancreas, but is present in both healthy and diabetes-affected individuals. IAPP, released by pancreatic B-cells, is secreted with insulin to maintain healthy glucose levels within the body, but cell conditions can cause IAPP to have amyloidogenic properties, thus killing such B-cells. Cations such as Na+, Zn+, Cu2+, have shown potential properties that can reduce or slow IAPP aggregation within the cell.
