Document Type
Article
Publication Date
5-8-2012
Abstract
Intracellular calcium (Ca) cycling dynamics in cardiac myocytes is regulated by a complex network of spatially distributed organelles, such as sarcoplasmic reticulum (SR), mitochondria, and myofibrils. In this study, we present a mathematical model of intracellular Ca cycling and numerical and computational methods for computer simulations. The model consists of a coupled Ca release unit (CRU) network, which includes a SR domain and a myoplasm domain. Each CRU contains 10 L-type Ca channels and 100 ryanodine receptor channels, with individual channels simulated stochastically using a variant of Gillespie’s method, modified here to handle time-dependent transition rates. Both the SR domain and the myoplasm domain in each CRU are modeled by 5 × 5 × 5 voxels to maintain proper Ca diffusion. Advanced numerical algorithms implemented on graphical processing units were used for fast computational simulations. For a myocyte containing 100 × 20 × 10 CRUs, a 1-s heart time simulation takes about 10 min of machine time on a single NVIDIA Tesla C2050. Examples of simulated Ca cycling dynamics, such as Ca sparks, Ca waves, and Ca alternans, are shown.
Publisher Statement
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Rovetti, Robert [et al]. (2012) "Computational Modeling and Numerical Methods for Spatiotemporal Calcium Cycling in Ventricular Myocytes." Frontiers in Physiology 3
Digital Commons @ LMU & LLS Citation
Rovetti, Robert, "Computational Modeling and Numerical Methods for Spaciotemporal Calcium Cycling in Ventricular Myocytes" (2012). Mathematics, Statistics and Data Science Faculty Works. 16.
https://digitalcommons.lmu.edu/math_fac/16
